Paddington is an area in the City of Westminster, in central London, England. A medieval parish then a metropolitan borough of the County of London, it was integrated with Westminster and Greater London in 1965. Paddington station, designed by the engineer Isambard Kingdom Brunel opened in 1847. It is also the site of St Mary's Hospital and the forme…Paddington is an area in the City of Westminster, in central London, England. A medieval parish then a metropolitan borough of the County of London, it was integrated with Westminster and Greater London in 1965. Paddington station, designed by the engineer Isambard Kingdom Brunel opened in 1847. It is also the site of St Mary's Hospital and the former Paddington Green Police Station.