The attack came just days after President Biden gave Ukraine permission to use the weapons to strike targets inside Russia.

Ukraine has fired US-made ATACMS missiles into Russia’s Bryansk region, Russia’s Defense Ministry said, in a major escalation on the 1,000th day of war.

Ukraine has fired US-supplied long-range missiles into Russia for the first time since Joe Biden lifted restrictions on their use – with Moscow warning that it would respond “accordingly” on a day where Vladimir Putin lowered the bar for the Kremlin to launch an attack using nuclear weapons.