Long before carriers of autosomal-dominant AD mutations notice the first hints of memory loss, changes in their brains are ...
About two-thirds of people with Alzheimer’s disease are women, yet due to the challenges in studying X chromosomes, a genetic ...
Driving the Amyloid Cascade? A microglial subtype, Mic.12, promotes plaque deposition, while another, Mic.13, promotes ...
The findings indicate that early changes in brain activity—happening in parallel with Aβ and tau accumulation—can predict future cognitive decline. “This suggests that we may be able to detect ...
Two Types. Confocal microscopy reveals α-synuclein (green) and lipids (red) in three adjacent inclusions (left and right). The white arrows point to Type I inclusions loaded with lipids. Blue ...
Immunotherapy can remove extracellular amyloid plaques from Alzheimer’s brain, but has so far failed to clear intracellular tau tangles. Now, two papers propose a solution: tagging them for ...
To boost the statistical power to find Alzheimer’s genes, geneticists often use endophenotypes—measurable characteristics of the disease—in place of clinical diagnoses. Case in point: A genome-wide ...
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