Starting Tuesday in Louisiana, mifepristone and misoprostol will be reclassified as controlled substances in the state, making it a crime punishable by up to five years in prison to possess the drugs without a prescription.

Louisiana will become the first in the United States on Tuesday to categorize two widely used abortion-inducing pills as “controlled dangerous substances.”

A new law will go into effect in Louisiana on Oct. 1 that will classify two drugs—mifepristone and misoprostol, which are commonly used for abortions, postpartum hemorrhaging, and miscarriage management—as “controlled dangerous substances.” The change is worrying doctors who say the repercussions could be life-threatening for some.