The Colts listed seven players as inactive versus the Steelers. Here is what you need to know and the potential impact on today’s game.

INDIANAPOLIS -- The Pittsburgh Steelers have ruled out seven players against the Indianapolis Colts, including three starters among those out. Running back Jaylen Warren (knee), outside linebacker Alex Highsmith (groin), tight end MyCole Pruitt (knee), quarterback Russell Wilson (calf), and guard Isaac Seumalo (pec) are all out with injuries.

When the Pittsburgh Steelers take on the Indianapolis Colts in Week Four, they will do so with two rookies on the offensive line. According to Steelers beat reporter Gerry Dulac, guard Mason McCormick will get the start at left guard over Spencer Anderson.