Houston Texans running back Joe Mixon will miss his second consecutive game, inactive for Sunday's home contest against the winless Jacksonville Jaguars. The Texans (2-1) had listed Mixon as questiona

The Houston Texans will be without star running back Joe Mixon for their matchup against the Jacksonville Jaguars. Mixon has been dealing with an ankle injury that he suffered during Week 2 against the Chicago Bears.

In Week 4, running back Joe Mixon and the Houston Texans' rushing attack will match up with the Jacksonville Jaguars and their 11th-ranked run defense (109.3 rushing yards allowed per game). The contest has a start time of 1:00 PM ET on Sunday.