ALZFORUM6d
CSF Proteins Spot Alzheimer’s Mutation Carriers Decades Before Symptoms
Long before carriers of autosomal-dominant AD mutations notice the first hints of memory loss, changes in their brains are ...
ALZFORUM7d
Glial Cell Communities Conspire to Drive Alzheimer’s Disease
The amyloid cascade—plaques to tangles to cognitive decline—has become well established. Less well understood is what role inflammation and glial changes play. Now, by analyzing single-nuclei RNA-Seq ...
ALZFORUM6d
Synaptic Skirmish: Aβ and Tau Pathologies Battle Over Brain Rhythms
The findings indicate that early changes in brain activity—happening in parallel with Aβ and tau accumulation—can predict future cognitive decline. “This suggests that we may be able to detect ...
ALZFORUM6d
New Alzheimer’s Gene? Cytochrome P450 Protein Linked to Tangles
Hot Spot. GWAS of tau PET scans found a single locus where SNPs (circles) were associated with higher tangle loads. The strongest signal came from SNP rs2113389 (gray diamond). [Courtesy of Nho et al.
ALZFORUM4d
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ALZFORUM7d
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BSc Biomedical Sciences at Lancaster University MSc Neuroscience and Translational Medicine at Queen Mary University of London Now, I'm currently a PhD student at the University of Dundee, looking ...